Lives listing by nationality: Irish
- Sullivan, John (born 1749–died 1839), Irish East India Company official, diplomat, politician, member of Parliament
- Supple, Katherine [née Smyth] (flourished 1622–1656), Irish gentlewoman
- Sutton, Isabella (born c. 1728–died 1768), Irish gentlewoman
- Swanton, Honoria [née Swift] (died 1756), Irish home-maker
- Swift, Abigail [née Erick (or Herrick)] (born 1640–died 1710), Irish home-maker
- Swift, Deane [the elder] (born 1674–died 1714), Irish gentleman
- Swift, Deane [the younger] (born 1707–died 1783), Irish author, biographer
- Swift, Jonathan (born 1667–died 1745), Irish author, poet, satirist
- Swift, Mary [née Harrison] (flourished 1736–1742), Irish home-maker
- Swift, Reverend Thomas (born 1665–died 1752), Irish churchman
- Swift, William (died 1706), Irish [unknown occupation]
- Symner, Reverend Miles (born c. 1600–died 1686), Irish churchman, army officer, university teacher
- Sympson, Richard [Jonathan Swift] (pseudonym/initials used c. 1726–c. 1727), Irish author, poet, satirist
- Synge, Reverend Edward, archbishop of Tuam (born 1659–died 1741), Irish churchman
- Synge, Reverend Nicholas, bishop of Killaloe (born c. 1693–died 1771), Irish churchman
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