Lives listing by nationality: American
- Cranch, Mary Smith (born 1740–died 1811), American home-maker
- Cranch, Richard (born 1726–died 1811), American glassmaker, politician, tradesman
- Crocker, Joseph (born 1749–died 1797), American [unknown occupation]
- Croghan, Colonel George (died 1782), American civil servant, landowner
- Cross, Ralph (flourished 1789), American merchant
- Cross, Stephen (born 1731–died 1809), American [unknown occupation]
- Crow, William (flourished 1761–1763), American cattle dealer, tradesman
- Cudworth, James (born 1612–died 1682), American politician, army officer, soldier
- Culpeper County, Virginia, justices of (active 1765), American judge, lawyer
- Culver, Jonathan (born c. 1745–died 1807), American [unknown occupation]
- The Cumberland Gazette (founded 1785), American newspaper
- Cumming, John Noble (born 1752–died 1821), American [unknown occupation]
- Cumming, William (born 1724–died c. 1797), American lawyer, politician
- Cunningham, William (born 1767–died 1823), American [unknown occupation]
- Curson, Richard (born c. 1725–died 1805), American [unknown occupation]
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